G-418 DiSulphate

SKU Pack Size Price
G4185 5g $155.93
G4181 1g $31.19

G-418 is a member of the large family of Aminoglycoside antibiotics and has a molecular structure almost like Gentamycin. The antibiotic is an irreversible inhibitor of protein synthesis. Due to its structure is capable of binding to both prokaryotic and eukaryotic ribosomes and inhibiting protein synthesis and generating errors in the transcription of the genetic code.

G-418 can by inactivated by NPTII or 3APH. The hydroxyl group present at the 3 position of G-418 is phosphorylated by NPTII. The resulting steriometric change of the molecular structure of the antibiotic prevents it from binding at its ribosome binding site.


Character Fine white powder
Solubility Freely soluble in water
Specific Optical Rotation 104 ~ 121
Water <6%
Absorbance 570 nm <0.10
Absorbance 280 nm <0.015
NH4 < 1.0%
pH  5.5 0.5
Thin Layer Chromatogram One Spot
Potency >720 µ/mg

Store at 2 – 8°C
Protect from light
CAS 108321-42-2

English Download
17/MFM/1998 Download
18/MFM/2072 Download
18/MFM/2130 Download
18/MFM/2188 Download

From: $31.19

From: $31.19