Complete Supplement Mixture (CSM) is a combination of Amino Acids, Vitamins and other essential components to support a vigorous growth of cells in CSM supplemented medium. Yeast Nitrogen Base media without Amino Acids supplemented with CSM have been proven to be an excellent combination for the cultivation of almost all strains of Saccharomyces Cerevisiae and to supplement encountered auxothrophies.
CSM is also a basis for many “Drop-Out” mixtures to select for auxotrophic requirements and transformants. Each CSM Drop-Out mixture contain all components except for one to five essential nutrients, i.e. the “dropped out” supplements. Some CSM Drop-Out mixtures are also available with additions of extra Amino Acids and other components.